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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoVAs disease progressed, a series of complications tend to develop, especially in critically ill patientsApart from supportive care, no specific treatment has been established for COVID-19.

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 533-541 doi: 10.1007/s11684-020-0786-5

Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoVresponses in the host involving increased cytokine release, tissue damage, and high neurosusceptibility to COVID-19-19, especially in the hypoxic conditions caused by lung injury.

Keywords： coronavirus disease 2019 (COVID-19)     SARS-CoV-2     neurological manifestations     neuroinvasion     brain    

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Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 210-214 doi: 10.1007/s11684-020-0757-x

Abstract: In December 2019, an outbreak of novel coronavirus (2019-nCoV) occurred in Wuhan, Hubei Province, ChinaHere we report the first family case of coronavirus disease 2019 (COVID-19) confirmed in Wuhan and treatedcourse, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19-19, and warrants further clinical trials.

Keywords： novel coronavirus (2019-nCoV)     COVID-19     Chinese traditional patent medicine     Shuanghuanglian oral liquid    

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Organ function support in patients with coronavirus disease 2019: Tongji experience

Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 232-248 doi: 10.1007/s11684-020-0774-9

Abstract: Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human healthCOVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver andThe World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%.To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide

Keywords： COVID-19     severe and critical type     organ function support    

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COVID-19 containment: China provides important lessons for global response

Shuxian Zhang, Zezhou Wang, Ruijie Chang, Huwen Wang, Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Yinqiao Dong, Hui Wang, Yong Cai

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 215-219 doi: 10.1007/s11684-020-0766-9

Abstract: The world must act fast to contain wider international spread of the epidemic of COVID-19 now.It is really important to take collaborative actions now to save more lives from the pandemic of COVID-19.

Keywords： coronavirus disease 2019 (COVID-19)     control measure     public health response    

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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

Frontiers of Medicine doi: 10.1007/s11684-023-1043-5

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwideviral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirusdisease 2019 (COVID-19).variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19-19 patients are also discussed, along with advances in therapeutic agents.

Keywords： coronavirus disease 2019     SARS-CoV-2     epidemiology     clinical features    

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Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 193-198 doi: 10.1007/s11684-020-0772-y

Abstract: -19.Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19.Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 motherswere clinically diagnosed with COVID-19.None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19

Keywords： coronavirus disease 2019     severe acute respiratory syndrome-associated coronavirus     maternal-infant infection    

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China’s local governments are combating COVID-19 with unprecedented responses – from a Wenzhou governance

Fanghua Gong, Yong Xiong, Jian Xiao, Li Lin, Xiaodong Liu, Dezhong Wang, Xiaokun Li

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 220-224 doi: 10.1007/s11684-020-0755-z

Abstract: The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its onset in Wuhan, the capital city of central China’s Hubei Province, in December 2019.

Keywords： COVID-19     novel coronavirus pneumonia     2019-nCoV     epidemic management    

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Rapid Layout and Development Strategy of Hospital Artificial Intelligence During the COVID-19 Pandemic

Chen Xinhua, Jiang Jianwen, Zhou Hua, Xie Haiyang, Zhou Lin, Guo Danjing, Xue Chen Zhu Weiwei, Zhou Jianying , Zheng Shusen

Strategic Study of CAE 2020, Volume 22, Issue 2,   Pages 130-137 doi: 10.15302/J-SSCAE-2020.02.021

Abstract: > This study aims to explore the application of artificial intelligence (AI) in the context of coronavirusdisease 2019 (COVID-19) pandemic, with a view for promoting the top-level design and rapid layout ofSince the outbreak of the COVID-19 epidemic, China has conducted epidemic prevention and control using

Keywords： hospital construction     coronavirus disease 2019 (COVID-19)     artificial intelligence (AI)     application status    

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The Scientific Foundation of Chinese Herbal Medicine against COVID-19 Perspective

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Engineering 2020, Volume 6, Issue 10,   Pages 1099-1107 doi: 10.1016/j.eng.2020.08.009

Abstract: disease 2019 (COVID-19) pandemic outbreak has caused a serious global health emergency.Supporting evidence shows that COVID-19 shares a genomic similarity with other coronaviruses, such asAccording to the clinical pathological features of COVID-19 patients, patients can suffer from five stepsmedicine could be used as an alternative treatment option or in combination with Western medicine to treat COVID-19-19.

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus     Chinese herbal medicine     Antiviral    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tacklingthe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and mutation, with severalprotein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19.the ultimate aim of delivering robust and durable protection that is resilient to emerging infectious disease

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: Vaccination is the most effective and feasible way to contain the coronavirus disease 2019 (COVID-19)The rapid development of effective COVID-19 vaccines is an extraordinary achievement.study reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed COVID-19-19 vaccines and discussed the challenges and prospects of the vaccine-based approaches in a global crisis

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 776-785 doi: 10.1007/s11684-020-0820-7

Abstract: Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirusHowever, approaches to distinguish COVID-19 from pneumonia caused by other pathogens have not yet beenIn the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG against SARS-CoVIn 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM.These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted.

Keywords： coronavirus disease 2019     pediatrics     emergency     retrospective investigation     severe acute respiratory syndromecoronavirus 2    

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Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 629-637 doi: 10.1007/s11684-020-0825-2

Abstract: Cardio-cerebrovascular disease (CCVD) is a major comorbidity of coronavirus disease 2019 (COVID-19).In this study, 102 cases of COVID-19 from January 22, 2020 to March 26, 2020 in Xixi Hospital of Hangzhouthe outcomes between groups, CCVD patients received more intensive comprehensive treatment to improve COVID-19-19.In addition, given that COVID-19 patients are usually related to coagulation disorders and thrombosis

Keywords： COVID-19     cardio-cerebrovascular disease     traditional Chinese medicine     clinical features     clinical therapeutics    

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A Predictive Nomogram for Predicting Improved Clinical Outcome Probability in Patients with COVID-19 Article

Jiaojiao Xie, Ding Shi, Mingyang Bao, Xiaoyi Hu, Wenrui Wu, Jifang Sheng, Kaijin Xu, Qing Wang, Jingjing Wu, Kaicen Wang, Daiqiong Fang, Yating Li, Lanjuan Li

Engineering 2022, Volume 8, Issue 1,   Pages 122-129 doi: 10.1016/j.eng.2020.05.014

Abstract: disease 2019 (COVID-19).Data on 104 patients admitted to hospital with laboratory-confirmed COVID-19 infection from 10 Januarylogistics regression model were used to select prognostic factors for predicting clinical outcomes in COVID-19-19 patients.nomogram we constructed is useful for clinicians to predict improved clinical outcome probability for each COVID-19

Keywords： Coronavirus disease 2019 (COVID-19)     Nomogram     Patient-relevant outcome    

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Title Author Date Type Operation

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

Journal Article

Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

Journal Article

Organ function support in patients with coronavirus disease 2019: Tongji experience

Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science

Journal Article

COVID-19 containment: China provides important lessons for global response

Shuxian Zhang, Zezhou Wang, Ruijie Chang, Huwen Wang, Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Yinqiao Dong, Hui Wang, Yong Cai

Journal Article

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

Journal Article

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

Journal Article

China’s local governments are combating COVID-19 with unprecedented responses – from a Wenzhou governance

Fanghua Gong, Yong Xiong, Jian Xiao, Li Lin, Xiaodong Liu, Dezhong Wang, Xiaokun Li

Journal Article

Rapid Layout and Development Strategy of Hospital Artificial Intelligence During the COVID-19 Pandemic

Chen Xinhua, Jiang Jianwen, Zhou Hua, Xie Haiyang, Zhou Lin, Guo Danjing, Xue Chen Zhu Weiwei, Zhou Jianying , Zheng Shusen

Journal Article

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

Journal Article

Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan

Journal Article

A Predictive Nomogram for Predicting Improved Clinical Outcome Probability in Patients with COVID-19

Jiaojiao Xie, Ding Shi, Mingyang Bao, Xiaoyi Hu, Wenrui Wu, Jifang Sheng, Kaijin Xu, Qing Wang, Jingjing Wu, Kaicen Wang, Daiqiong Fang, Yating Li, Lanjuan Li

Journal Article